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Unilateral periodic limb movements during sleep in corticobasal degeneration
Author(s) -
Iriarte Jorge,
Alegre Manuel,
Arbizu Javier,
de Castro Purificación
Publication year - 2001
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.1227
Subject(s) - corticobasal degeneration , basal ganglia , neuroscience , sleep (system call) , positron emission tomography , medicine , basal (medicine) , psychology , pathology , progressive supranuclear palsy , central nervous system , disease , computer science , insulin , operating system
Periodic limb movements in sleep (PLM) have been associated with several degenerative disorders and other focal or diffuse diseases. We present a patient with clinical diagnosis of corticobasal degeneration and sleep complaints, in whom video recording and polygraphic study confirmed the presence of right PLM. The unilaterality of the movements and the positron emission tomography findings (hypometabolism in the left frontoparietal, basal ganglia, and thalamic areas) suggest that the loss of inhibitory descending central pathways, with origin in the cortex or basal ganglia, may be involved in the pathogenesis of PLM. © 2001 Movement Disorder Society.