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Functional magnetic resonance imaging during deep brain stimulation: A pilot study in four patients with Parkinson's disease
Author(s) -
Jech Robert,
Urgošík Dušan,
Tintěra Jaroslav,
Nebuželský Antonín,
Krásenský Jan,
Liščák Roman,
Roth Jan,
Růžička Evžen
Publication year - 2001
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.1217
Subject(s) - deep brain stimulation , subthalamic nucleus , functional magnetic resonance imaging , neuroscience , stimulation , thalamus , magnetic resonance imaging , parkinson's disease , nucleus , psychology , medicine , disease , pathology , radiology
Functional magnetic resonance imaging (fMRI) was performed in patients with Parkinson's disease during deep brain stimulation of the subthalamic nucleus (three patients) and during deep brain stimulation of the ventral intermedius nucleus of the thalamus (one patient). All showed an increase in blood oxygenation level‐dependent signal in the subcortical regions ipsilateral to the stimulated nucleus. This effect cannot be simply explained by a mechanism of depolarization blockade; rather, it is caused by overstimulation of the target nucleus, resulting in the suppression of its spontaneous activity. We confirm that fMRI during deep brain stimulation is a safe method with considerable potential for elucidating the functional connectivity of the stimulated nuclei. © 2001 Movement Disorder Society.