Riluzole therapy in cervical dystonia | Zendy

Müller Jörg | Zendy; Wenning Gregor K. | Zendy; Wissel Jörg | Zendy; Baldauf Angelika | Zendy; Seppi Klaus | Zendy; Brenneis Christian | Zendy; Poewe Werner | Zendy

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Riluzole therapy in cervical dystonia

Author(s) -

Müller Jörg,

Wenning Gregor K.,

Wissel Jörg,

Baldauf Angelika,

Seppi Klaus,

Brenneis Christian,

Poewe Werner

Publication year - 2002

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.1200

Subject(s) - riluzole , cervical dystonia , medicine , refractory (planetary science) , dystonia , botulinum toxin , rating scale , dyskinesia , neurological disorder , anesthesia , physical therapy , central nervous system disease , amyotrophic lateral sclerosis , psychology , parkinson's disease , psychiatry , developmental psychology , physics , disease , astrobiology

We conducted a 6‐week open‐label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole ( P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies. © 2001 Movement Disorder Society.

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