Premium
Parkinsonism after glycine‐derivate exposure
Author(s) -
Barbosa Egberto R.,
Leiros da Costa Maria D.,
Bacheschi Luiz A.,
Scaff Milberto,
Leite Claudia C.
Publication year - 2001
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.1105
Subject(s) - globus pallidus , parkinsonism , benserazide , substantia nigra , glycine , levodopa , magnetic resonance imaging , medicine , nuclear medicine , chemistry , basal ganglia , pathology , parkinson's disease , radiology , biochemistry , amino acid , central nervous system , disease
This 54‐year‐old man accidentally sprayed himself with the chemical agent glyphosate, a herbicide derived from the amino acid glycine. He developed disseminated skin lesions 6 hours after the accident. One month later, he developed a symmetrical parkinsonian syndrome. Two years after the initial exposure to glyphosate, magnetic resonance imaging revealed hyperintense signal in the globus pallidus and substantia nigra, bilaterally, on T2‐weighted images. Levodopa/benserazide 500/125 mg daily provided satisfactory clinical outcome.