Premium
Neuronal globus pallidus activity in patients with generalised dystonia
Author(s) -
Merello Marcelo,
Cerquetti Daniel,
Cammarota Angel,
Tenca Eduardo,
Artes Carlos,
Antico Julio,
Leiguarda Ramon
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10700
Subject(s) - globus pallidus , dystonia , striatum , tonic (physiology) , neuroscience , basal ganglia , inhibitory postsynaptic potential , excitatory postsynaptic potential , medicine , psychology , central nervous system , dopamine
We studied 516 globus pallidus neurons in dystonic patients. The firing rate was analysed. We classified the burst activity into tonic, burst, and pause patterns. Mean ± SD firing rates and tonicity score for internal globus pallidus (GPi) and external globus pallidus (GPe) were 54.6 ± 28.6; 58.01 ± 39.1 and 1.18 ± 0.55; 0.95 ± 0.43, respectively. Differences in percentage appearance of tonic, burst, or paused neurons were not statistically significant for GPi versus GPe. GPi firing features in dystonic patients were closely similar to those of GPe. This could suggest that the abnormally patterned output from GPi would not result from increased differential inhibitory/excitatory input arising from the direct/indirect pathway but rather be transmitted from GPe, striatum, or either centromedian nucleus. © 2003 Movement Disorder Society