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Consensus statement on the role of acute dopaminergic challenge in Parkinson's disease
Author(s) -
Albanese Alberto,
Bonuccelli Ubaldo,
Brefel Christine,
Chaudhuri K. Ray,
Colosimo Carlo,
Eichhorn Tobias,
Melamed Eldad,
Pollak Pierre,
Van Laar Teus,
Zappia Mario
Publication year - 2001
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.1069
Subject(s) - parkinson's disease , medicine , intensive care medicine , disease , apomorphine , levodopa , clinical practice , statement (logic) , dopaminergic , medline , psychiatry , physical therapy , pathology , dopamine , political science , law
Available evidence on the practice of acute pharmacological challenge tests in parkinsonian patients was reviewed by a committee of experts, which achieved a general consensus. The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease. Such challenge may serve different purposes, e.g., research, diagnosis, or tailoring of treatment. Unique protocols describing the clinical setting and practice parameters are not available. The present paper describes the scientific background and supplies practical guidelines, whenever possible, to perform and evaluate acute challenge tests in parkinsonian syndromes. With the appropriate indication and setting, acute challenge tests are useful in diagnosis and therapy of Parkinson's disease and related disorders. © 2001 Movement Disorder Society.