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Adverse effects of dopamine potentiation by long‐term treatment with selegiline
Author(s) -
Hollán Susan,
Vécsei László,
Magyar Kálmán
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10641
Subject(s) - selegiline , medicine , adverse effect , dopamine , long term potentiation , monoamine oxidase b , monoamine oxidase , anesthesia , parkinson's disease , psychiatry , disease , chemistry , biochemistry , receptor , enzyme
A patient with triosephosphate isomerase (TPI) deficiency exhibited worsening of abnormal involuntary movements of the dystonic type and developed psychiatric symptoms while on selegiline. When selegiline was stopped after 9 years of treatment, abnormal involuntary movements improved to pretreatment level and psychiatric behaviour returned to normal. Monoamine oxidase‐B platelet activity was low in this patient. © 2003 Movement Disorder Society