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Impact of genetic analysis on Parkinson's disease research
Author(s) -
Hardy John
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10569
Subject(s) - parkin , disease , context (archaeology) , parkinson's disease , pathogenesis , pink1 , genetics , degenerative disease , neuroscience , bioinformatics , medicine , biology , pathology , paleontology
Genetic analysis is changing our view of Parkinson's disease: not only is it challenging the long‐cherished views about the diagnosis of the disease, it is also starting to suggest a biochemical pathway to disease pathogenesis. These developments are reviewed in the context of three known (synuclein, parkin, and DJ‐1) and one suspected (ubiquitin hydrolase) genes for the disease. © 2003 Movement Disorder Society
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