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Anatamopathological spectrum of tauopathies
Author(s) -
Revesz Tamas,
Holton Janice L.
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10558
Subject(s) - progressive supranuclear palsy , parkinsonism , frontotemporal dementia , tau protein , pathology , dementia , tauopathy , corticobasal degeneration , disease , neuroscience , pathogenesis , medicine , biology , alzheimer's disease , neurodegeneration
The presence of tau‐positive intraneuronal filamentous inclusions with or without additional inclusions in glial cells has been recognised as a major neuropathological feature in a significant group of neurodegenerative diseases, which are described as tauopathies. In one category of such diseases, the neuronal inclusions occur in association with extracellular deposition of a second aggregated protein (secondary tauopathies), whereas in another, the filamentous inclusions composed of tau are the sole neuropathological abnormality (primary tauopathies). Genetic studies of tauopathies in general, and in frontotemporal dementia with parkinsonism linked to chromosome 17 in particular, have significantly contributed to our knowledge about the pathogenesis not only of rare hereditary conditions but also of other more common diseases such as Alzheimer's disease and progressive supranuclear palsy. © 2003 Movement Disorder Society