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Coherence analysis in the myoclonus of corticobasal degeneration
Author(s) -
Grosse Pascal,
Kühn Andrea,
Cordivari Carla,
Brown Peter
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10535
Subject(s) - myoclonus , electromyography , electroencephalography , corticobasal degeneration , neuroscience , psychology , coherence (philosophical gambling strategy) , stimulus (psychology) , physical medicine and rehabilitation , audiology , medicine , atrophy , physics , progressive supranuclear palsy , pathology , cognitive psychology , quantum mechanics
We investigated whether myoclonus in corticobasal degeneration (CBD) is cortical or subcortical in origin. Many authors have suggested that the myoclonus in CBD is a subtype of cortical myoclonus, despite the fact that back‐averaging fails to detect a cortical correlate to spontaneous or action induced jerks and giant sensory evoked potentials are seldom found. Electroencephalographic–electromyographic (EEG–EMG) and EMG–EMG frequency analysis may be more sensitive to cortical drives when EMG bursts occur at a high frequency and at low amplitudes as in CBD. We evaluated EEG–EMG and EMG–EMG coherence and phase in 5 patients with clinically probable CBD and unilateral, action‐induced and stimulus‐sensitive myoclonus. We found negligible corticomuscular coherence despite a dramatically exaggerated EMG–EMG coherence. We conclude that an inflated EMG–EMG coherence is found in some patients with CBD and that this is unlikely to be due to an exaggerated cortical drive. © 2003 Movement Disorder Society