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Subthalamic somatosensory evoked potentials in Parkinson's disease
Author(s) -
Pesenti Alessandra,
Priori Alberto,
Locatelli Marco,
Egidi Marcello,
Rampini Paolo,
Tamma Filippo,
Caputo Elena,
Chiesa Valentina,
Barbieri Sergio
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10519
Subject(s) - subthalamic nucleus , deep brain stimulation , parkinson's disease , neuroscience , somatosensory evoked potential , somatosensory system , basal ganglia , medicine , local field potential , degenerative disease , stimulation , central nervous system disease , sensory system , psychology , disease , central nervous system , pathology
Deep brain stimulation (DBS) of subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. It also provides an opportunity to record neural activity from the human basal ganglia. In this study, to investigate the involvement of the human STN in sensory functions, we recorded somatosensory evoked potentials (SEPs) elicited by contralateral median‐nerve stimulation, from STN electrodes implanted for DBS in patients with Parkinson's disease. We suggest that the STN N18 component of SEPs in Parkinson's disease is a mainly local field potential elicited by muscle afferent input to the nucleus. © 2003 Movement Disorder Society