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Brain perfusion SPECT in patients with corticobasal degeneration: Analysis using statistical parametric mapping
Author(s) -
Hossain A.K.M. Moinul,
Murata Yuji,
Zhang Lin,
Taura Shinichi,
Saitoh Yukinobu,
Mizusawa Hidehiro,
Oda Kenji,
Matsushima Eisuke,
Okubo Yoshiro,
Shibuya Hitoshi
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10415
Subject(s) - cerebral blood flow , statistical parametric mapping , corticobasal degeneration , thalamus , basal ganglia , perfusion , single photon emission computed tomography , nuclear medicine , medicine , perfusion scanning , emission computed tomography , cardiology , central nervous system , radiology , dementia , magnetic resonance imaging , disease
We sought to determine the characteristics of brain perfusion in patients with corticobasal degeneration (CBD) using single photon emission computed tomography (SPECT) and statistical parametric mapping (SPM). Thirteen patients with CBD and 10 age‐matched healthy volunteers were examined using brain perfusion SPECT and 99m Tc‐ethyl cysteinate dimer (ECD). Regional cerebral blood flow (rCBF) measurements were performed noninvasively using a graphic analysis method. Both the absolute rCBF data (raw data) and the adjusted rCBF data (global CBF normalized to 50 ml/100 g/min) were used in the SPM analysis. A significant decrease in the absolute rCBF was observed in extended areas of the brain in CBD patients compared to the control group. These areas included the frontal, parietal, and temporal cortices; basal ganglia; thalamus; and pontocerebellar regions. Our results suggest that the extent of the reduced rCBF region in CBD patients is more widespread than previously reported. © 2003 Movement Disorder Society