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Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease
Author(s) -
Tan EngKing,
Tan Yanni,
Chai Anthea,
Tan Christopher,
Shen Hui,
Lum SauYing,
FookCheong Stephanie M.C.,
Teoh MeiLing,
Yih Yuan,
Wong MengCheong,
Zhao Yi
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10406
Subject(s) - linkage disequilibrium , medicine , parkinson's disease , disequilibrium , genetic association , genetics , haplotype , endocrinology , allele , disease , biology , single nucleotide polymorphism , genotype , gene , surgery
In a case control study, we examined the association of DRD2 Taq1A and Taq1B polymorphisms and risk of PD, and evaluated the strength of linkage disequilibrium of the polymorphisms. The Taq1A and Taq1B polymorphisms were in strong linkage disequilibrium. There was, however, no significant association of the two polymorphisms with PD. © 2003 Movement Disorder Society