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Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: Different action on GABA cell subpopulations
Author(s) -
Díaz Manuel Rodríguez,
BarrosoChinea Pedro,
Acevedo Abraham,
GonzálezHernández Tomás
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10345
Subject(s) - substantia nigra , gabaergic , dopaminergic , neuroscience , nigrostriatal pathway , glutamate decarboxylase , neurochemical , pars reticulata , dopamine , biology , inhibitory postsynaptic potential , biochemistry , enzyme
The motor disturbances occurring in Parkinson's disease have been partially attributed to a hyperactivity of γ‐aminobutyric acid (GABA) ‐ergic nigral cells largely in the substantia nigra pars reticulata (SNr) secondary to the degeneration of dopaminergic nigrostriatal neurons. However, some aspects of this response remain unclear. In this work, different electrophysiological and neurochemical parameters were studied in GABAergic cells of the SN after unilateral nigrostriatal dopaminergic lesion using 6‐hydroxydopamine injection in rats. Our data showed that 1) the SN under normal conditions contains different subsets of GABAergic cells according to their firing pattern and glutamic acid decarboxylase mRNA levels, and 2) the response of these GABAergic cell subgroups was different after the ipsi‐ and contralateral dopaminergic cell degeneration. These findings indicate a complex regulation of nigral GABAergic activity after nigrostriatal dopaminergic degeneration that probably involves local mechanisms, the nigro‐striato‐nigral loop, as well as interhemispheric mechanisms whose anatomical basis remains unstudied. © 2002 Movement Disorder Society