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Entacapone‐Induced Hepatotoxicity and Hepatic Dysfunction
Author(s) -
Fisher Alexander,
CroftBaker James,
Davis Michael,
Purcell Patrick,
McLean Allan J.
Publication year - 2002
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10342
Subject(s) - entacapone , medicine , hepatic dysfunction , levodopa , parkinson's disease , disease
We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol‐D‐methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports. © 2002 Movement Disorder Society