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Decreased striatal dopamine transporter binding in a patient with extrapontine myelinolysis
Author(s) -
Kim JoongSeok,
Lee KwangSoo,
Han SiRyung,
Chung YongAn
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10331
Subject(s) - parkinsonism , dopamine transporter , dopaminergic , tropane , dopamine , pathogenesis , dopamine plasma membrane transport proteins , neuroscience , transporter , medicine , endocrinology , psychology , chemistry , disease , biochemistry , gene
We describe the case of a 61‐year‐old woman who developed extrapontine myelinolysis (EPM) with parkinsonism. Decreased striatal dopamine transporter binding assessed by [ 123 I]N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(4‐chlorophenyl) tropane and single photon emission computed tomography ([ 123 I]IPT) SPECT) were observed in the patient, suggesting that osmotic injury causes the demyelination of nigrostriatal dopaminergic neurons and that such injury may be involved in the pathogenesis of EPM with parkinsonism.