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Secondary progressive chronic manganism associated with markedly decreased striatal D2 receptor density
Author(s) -
Kessler Kirn R.,
Wunderlich Gilbert,
Hefter Harald,
Seitz Rüdiger J.
Publication year - 2003
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10325
Subject(s) - medicine , neuroscience , receptor , endocrinology , psychology
We describe a patient with chronic manganism due to intoxication 40 years ago. Whereas previous reports on acute or subacute intoxication have shown no or only small reductions in striatal D2 receptor density, we found markedly decreased D2 receptor density using 18 F‐methylspiperone PET in this very late stage of chronic manganism, supporting the hypothesis that manganese intoxication may trigger a neurodegenerative disease process. © 2002 Movement Disorder Society