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Progressive delayed‐onset dystonia after cerebral anoxic insult in adults
Author(s) -
Kuoppamäki Mikko,
Bhatia Kailash P.,
Quinn Niall
Publication year - 2002
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10260
Subject(s) - dystonia , basal ganglia , internal capsule , basal ganglia disease , medicine , magnetic resonance imaging , pathology , anesthesia , cardiology , psychology , neuroscience , radiology , central nervous system , white matter
The basal ganglia, especially the globi pallidi (GP), are highly vulnerable to generalized cerebral anoxia/hypoxia. We report on 2 new cases with delayed‐onset generalized dystonia due to cerebral anoxia. The onset of dystonia in both of our patients was delayed by about 2 months. In both cases, the unusual feature was the progressive worsening and the spread of dystonia over many years after delayed onset. Dystonia progressed for 16 years in Case 1 and for 4 years in Case 2. Furthermore, initial magnetic resonance imaging (MRI) scan of Case 1 showed mild changes of the internal capsule sparing the basal ganglia. Years later, in line with clinical progression, the follow‐up MRI scan showed isolated bilateral lesions involving the entire GP. MRI scans in Case 2 showed bilateral lesions of caudate and lentiform nuclei. There may be several mechanisms underlying delayed and progressive symptoms after time‐limited brain anoxia. We hypothesize that anoxia‐induced excitotoxicity resulting in mitochondrial dysfunction and subsequent apoptosis may explain, at least partly, the delayed‐onset and progressive extrapyramidal syndromes seen in these patients. © 2002 Movement Disorder Society