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Quantitative 1 H magnetic resonance spectroscopy and MRI of Parkinson's disease
Author(s) -
O'Neill Joseph,
Schuff Norbert,
Marks William J.,
Feiwell Robert,
Aminoff Michael J.,
Weiner Michael W.
Publication year - 2002
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10214
Subject(s) - parkinson's disease , nuclear magnetic resonance , central nervous system disease , magnetic resonance imaging , degenerative disease , nuclear magnetic resonance spectroscopy , medicine , disease , physics , pathology , radiology
Magnetic resonance imaging (MRI) and 1 H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age‐matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between‐group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD‐linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current 1 H MRS methods. In additional, exploratory tests, volumes of the caudate (r = −0.56), putamen (r = −0.66), and globus pallidus (r = −0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects. © 2002 Movement Disorder Society