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Presynaptic parkinsonism in multiple system atrophy mimicking Parkinson's disease: A clinicopathological case study
Author(s) -
Berciano José,
Valldeoriola Francesc,
Ferrer Isidre,
Rumià Jordi,
Pascual Julio,
Marín Concepción,
Rey María J.,
Tolosa Eduardo
Publication year - 2002
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10190
Subject(s) - parkinsonism , subthalamic nucleus , substantia nigra , atrophy , locus coeruleus , pathology , medicine , neuroscience , neuropil , pons , central nervous system disease , parkinson's disease , psychology , deep brain stimulation , central nervous system , disease
We describe the clinicopathological findings in a patient aged 63 years at death who, at age 55 years, developed levodopa‐responsive parkinsonism with no atypical features. A diagnosis of idiopathic Parkinson's disease (PD) was made. During the clinical course, fluctuations and dyskinesias appeared. Eight years after onset, he was successfully treated with subthalamic nucleus stimulation but died 3 weeks postoperatively from pulmonary embolus. Brain autopsy showed marked neuronal loss and gliosis in the substantia nigra and locus coeruleus, and, to a much lesser extent, in the basis pontis, inferior olivary nuclei, and cerebellar cortex. Striatum was normal. There were numerous oligodendroglial and neuronal cytoplasmic inclusions and neuropil threads, the highest density being localized in the pons and cerebellar white matter. No Lewy bodies were observed. We conclude that nigral, presynaptic parkinsonism may occur in multiple system atrophy, which even in the long run can be indistinguishable from PD. Putaminal preservation accounts for good response to both levodopa therapy and subthalamic nucleus stimulation. © 2002 Movement Disorder Society

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