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Association between dopamine transporter gene polymorphism and susceptibility to Parkinson's disease in Japan
Author(s) -
Nishimura Masataka,
Kaji Ryuji,
Ohta Mitsuhiro,
Mizuta Ikuko,
Kuno Sadako
Publication year - 2002
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10187
Subject(s) - dopamine transporter , parkinson's disease , genotype , dopamine , polymorphism (computer science) , gene polymorphism , medicine , genetics , disease , degenerative disease , genetic predisposition , gene , biology , dopaminergic
We studied a polymorphism in the dopamine transporter (DAT) gene in 236 Japanese patients with Parkinson's disease (PD) and compared the results with 220 controls. The 1215A/G genotype of the DAT gene was significantly different between PD patients and controls, suggesting a possible involvement of DAT in genetic susceptibility to PD. © 2002 Movement Disorder Society