Premium
Therapeutic efficacy of bilateral prefrontal slow repetitive transcranial magnetic stimulation in depressed patients with Parkinson's disease: An open study
Author(s) -
Dragaševic Nataša,
Potrebić Aleksandra,
Damjanović Aleksandar,
Stefanova Elka,
Kostić Vladimir S.
Publication year - 2002
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10109
Subject(s) - transcranial magnetic stimulation , depression (economics) , parkinson's disease , prefrontal cortex , psychology , deep transcranial magnetic stimulation , beck depression inventory , antidepressant , rating scale , major depressive disorder , stimulation , deep brain stimulation , mood , medicine , psychiatry , anesthesia , neuroscience , disease , cognition , developmental psychology , anxiety , economics , macroeconomics
Recent studies have suggested that both high‐ and low‐frequency repetitive transcranial magnetic stimulation (rTMS) have antidepressant effects in patients with major depression. We conducted an open study to assess the effects of slow rTMS on mood changes in patients with depression associated with Parkinson's disease (PD). Ten depressed patients with PD (four with major depression and six with dysthymia) received daily sessions of rTMS (frequency, 0.5 Hz; pulse duration, 0.1 msec; field intensity, 10% above the motor threshold) over both prefrontal regions (a total of 100 stimuli per prefrontal region daily) over 10 consecutive days. This treatment resulted in a moderate but significant decrease in scores of the Hamilton Depression Rating Scale (33–37%) and the Beck Depression Inventory (24–34%), which persisted 20 days after finishing the stimulation. In parallel, we observed mild improvement (18–20%) of motor symptoms. No significant adverse effects were reported. These preliminary results suggest the therapeutic potential of daily prefrontal low‐frequency rTMS (0.5 Hz) in depression associated with PD. © 2002 Movement Disorder Society