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Physiological assessment of paroxysmal dystonia secondary to subacute sclerosing panencephalitis
Author(s) -
Ondo William G.,
Verma Amit
Publication year - 2002
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.10005
Subject(s) - subacute sclerosing panencephalitis , dystonia , ictal , basal ganglia , paroxysmal dyskinesia , medicine , electroencephalography , pediatrics , carbamazepine , movement disorders , psychology , neuroscience , anesthesia , epilepsy , pathology , measles , parkinson's disease , central nervous system , measles virus , dyskinesia , disease , vaccination
We report on a 26‐year‐old woman with subacute sclerosing panencephalitis (SSPE) who presented with frequent paroxysmal dystonic posturing. Electroencephalogram demonstrated generalized 5 to 10‐second episodes of high‐amplitude (150–300 μV) delta activity alternating with 10 to 20‐second periods of theta activity (40–50 μV). The patient experienced episodes of dystonic posturing coinciding with the periods of delta activity. Ictal Tc‐99m Ceretec SPECT demonstrated marked increased activity in the bilateral caudate (R>L). The frequency and amplitude of the episodes initially markedly improved after the addition of carbamazepine. We suggest that the movements seen in this case of SSPE may represent basal ganglia ictal activity. © 2001 Movement Disorder Society.