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Bullous Pemphigoid Associated with Multiple System Atrophy: Case Series
Author(s) -
Snedden Andrew,
Sharif Jennifer,
Newsham John,
Kobylecki Christopher
Publication year - 2021
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.13160
Subject(s) - bullous pemphigoid , atrophy , medicine , parkinson's disease , neurodegeneration , dermatology , pathogenesis , disease , pathology , immunology , antibody
Background Bullous pemphigoid (BP) is an autoimmune blistering dermatosis associated with a number of neurological conditions, including idiopathic Parkinson's disease (IPD). Only 1 case of BP in a patient with multiple system atrophy (MSA) has been reported. Cases We report 3 cases of men with probable MSA who developed bullous pemphigoid at a latency of 4–6 years from MSA symptom onset. Conclusions Skin α‐synuclein deposition in neurodegenerative conditions such as IPD and MSA may be a potential substrate for the exposure of BP‐related antigens. Alternatively, central neurodegeneration may expose antigens as a substrate for cross‐reactivity and BP pathogenesis. Our report suggests an association between BP and MSA, in addition to the previously documented association with IPD.