Premium
Extending the Phenotypic Spectrum Associated with STUB1 Mutations: A Case of Dystonia
Author(s) -
Olszewska Diana A.,
Kinsella Justin A.
Publication year - 2020
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12914
Subject(s) - dysarthria , dystonia , spinocerebellar ataxia , genetics , ataxia , phenotype , medicine , cerebellar ataxia , pediatrics , gene , biology , audiology , psychiatry
Background Mutations in the STIP1 homology and U‐box containing protein 1 gene were first described in 2013 and lead to disorders with symptoms including ataxia and dysarthria, such as spinocerebellar autosomal‐recessive ataxia type 16 (SCAR16), Gordon‐Holmes syndrome, and spinocerebellar ataxia type 48. There have been 15 families described to date with SCAR16. Cases We describe a 45‐year‐old right‐handed woman with dysarthria, ataxia, and cervical dystonia with SCAR16 with 2 compound heterozygous variants in the STIP1 homology and U‐box containing protein 1 gene, and a family history significant for her 47‐year‐old sister with dysarthria and cognitive problems. Conclusion We present a comprehensive overview of the phenotypic data of all 15 families with SCAR16 and expand the phenotype by describing a third patient with SCAR16 and dystonia reported to date in the literature.