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Pseudoagoraphobia, a Diagnostic Clue in Stiff‐Limb Syndrome
Author(s) -
Marano Massimo,
Motolese Francesco,
Lanzone Jacopo,
Di Santo Alessandro,
Rossi Mariagrazia,
Bevacqua Maria Gabriela,
Ranieri Federico,
Capone Fioravante,
Gatto Emilia Mabel,
Di Lazzaro Vincenzo
Publication year - 2020
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12911
Subject(s) - stiff person syndrome , phobias , physical medicine and rehabilitation , psychology , anxiety , medicine , psychiatry , biochemistry , chemistry , glutamate decarboxylase , enzyme
Background Stiff‐limb syndrome is part of stiff person spectrum, presenting with fluctuating gait disorders attributed to leg stiffness, spasms, and posturing. It could also manifest with anxiety and specific phobias such as pseudoagoraphobia. We aimed to describe the importance of specific gait phobia as a diagnostic clue to anti–glutamic acid decarboxylase stiff‐limb syndrome. Cases We reported on 2 cases of stiff‐limb syndrome sharing a similar diagnostic path and phenomenology. Both were featured by pseudoagoraphobia, which has documented to typically cover organic conditions, and a remarkable diagnostic delay attributed to misdiagnoses. Presence of pseudoagoraphobia should not point to the diagnosis of a functional disorder—although a negative instrumental workup is documented. Conclusions Both cases are emblematic of the high misdiagnosis rate affecting stiff person syndrome patients. A proper diagnostic process, including the identification of a pseudoagoraphobia, should help in reaching a diagnosis and providing an early and effective treatment.

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