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Antibody‐Negative Paraneoplastic Limbic Encephalitis, Parkinsonism, Hypothermia, and Narcolepsy Associated with Endometrial Carcinoma
Author(s) -
Brennan Declan,
Murphy Olwen C.,
Fearon Conor,
Brett Francesca,
Murray Brian,
Lynch Tim
Publication year - 2020
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12883
Subject(s) - limbic encephalitis , medicine , hypothermia , narcolepsy , parkinsonism , antibody , encephalitis , pathology , immunology , anesthesia , psychiatry , virus , autoantibody , neurology , disease
ABSTRACT Background We describe the clinical and neuropathological features of a patient with T‐cell‐mediated paraneoplastic limbic encephalitis, parkinsonism, hypothermia, and narcolepsy‐like presentation associated with endometrial carcinoma. Objectives This patient with prominent parkinsonism and narcolepsy broadens the phenotype of known paraneoplastic syndromes and demonstrates the importance of investigation for occult malignancy even in the absence of paraneoplastic antibodies. Methods This is a case report with diagnosis confirmed at postmortem. Results Paraneoplastic antibodies were not detected. The initial improvement with immunosuppression was short lived, and postmortem neuropathological examination demonstrated encephalitis with predominant T‐cell infiltration affecting the hypothalamus and extending to the brainstem, suggestive of a paraneoplastic syndrome. Conclusions Although the possibility of a novel antibody cannot be ruled out, consideration must also be given to recent demonstration of purely T‐cell‐mediated neuronal destruction in the context of paraneoplastic syndromes.