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The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease
Author(s) -
Halsband Claire,
Zapf Antonia,
SixelDöring Friederike,
Trenkwalder Claudia,
Mollenhauer Brit
Publication year - 2018
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12591
Subject(s) - rem sleep behavior disorder , cohort , parkinson's disease , medicine , polysomnography , rapid eye movement sleep , area under the curve , pediatrics , disease , psychiatry , electroencephalography , apnea
Background Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD). Objectives To test the validity of the RBD‐Screening Questionnaire (RBDSQ) in assessing RBD in early PD. Methods The RBDSQ was completed before video‐supported polysomnography (vPSG) by 134 de novo PD patients, 109 matched controls without neurological disorder (CTR) and 30 subjects with idiopathic RBD (iRBD) without clinical signs of PD; results were compared with vPSG‐confirmed RBD diagnosis. Results and Conclusions Sensitivity/specificity of the RBDSQ for the PD cohort were 0.44/0.84 at the previously published cut‐off score of 6 for PD patients, and the area under the curve (AUC) 0.68 (95% CI, 0.56–0.79). By contrast, in the iRBD/CTR cohort the RBDSQ (cut‐off = 5) had a sensitivity/specificity of 0.97/0.84 and an AUC of 0.95 (95% CI, 0.90–1.00). Subanalysis of question 6 only (4 subitems asking for dream enactment) at a cut‐off score of 1 revealed a sensitivity of 0.74 and a specificity of 0.70 for the de novo PD cohort, AUC was 0.74 (95% CI, 0.63–0.84). RBDSQ is an insufficient screening tool for RBD in de novo PD. New screening tools for RBD assessment need to be developed.