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Rotigotine Effects on Bladder Function in Patients with Parkinson's Disease
Author(s) -
Brusa Livia,
Petta Filomena,
Farullo Giuseppe,
Iacovelli Valerio,
Ponzo Viviana,
Iani Cesare,
Stanzione Paolo,
Agró Enrico Finazzi
Publication year - 2017
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12488
Subject(s) - rotigotine , parkinson's disease , urinary urgency , medicine , rating scale , overactive bladder , urology , anesthesia , disease , psychology , pathology , developmental psychology , alternative medicine
Abstract Background The objective of this study was to assess the effect of rotigotine treatment on bladder function in patients with Parkinson's disease ( PD ) who have urinary urgency. Methods in total, 20 patients with PD underwent urodynamic evaluation and completed International Prostate Symptoms questionnaires in off‐rotigotine condition and after 3 months of rotigotine patch monotherapy administration. In both sessions, clinical motor condition was evaluated with the Unified Parkinson Disease Rating Scale, Part III (motor part). Results Rotigotine administration significantly ameliorated the first sensation of bladder filling, the neurogenic detrusor overactive contractions threshold and bladder capacity compared with the off‐treatment condition. Moreover, the total score on the International Prostate Symptoms questionnaire revealed a decrease of filling (irritative) symptoms after rotigotine treatment compared with the off‐treatment condition. Conclusion The positive effects of rotigotine may be due to its balanced agonism to D1 and D2 receptors and in particular to its stimulation of D1 receptors in the anterior cingulate cortex and insula, which are known as areas involved in bladder‐inhibitory functions.