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Role of Corpus Callosum Volumetry in Differentiating the Subtypes of Progressive Supranuclear Palsy and Early Parkinson's Disease
Author(s) -
Lenka Abhishek,
Pasha Shaik Afsar,
Mangalore Sandhya,
George Lija,
Jhunjhunwala Ketan Ramakant,
Bagepally Bhawani Shankar,
Naduthota Rajini M.,
Saini Jitender,
Yadav Ravi,
Pal Pramod Kumar
Publication year - 2017
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12473
Subject(s) - progressive supranuclear palsy , corpus callosum , parkinson's disease , atrophy , pathology , medicine , psychology , disease
Background and Objective Progressive supranuclear palsy ( PSP ) is a progressive neurodegenerative disorder. Classic PSP or Richardson‐Steele phenotype ( PSP ‐ RS ) and parkinsonian phenotype ( PSP ‐P) are the common subtypes of PSP . At the early stage, differentiating the subtypes of PSP as well as differentiating PSP from other parkinsonian disorders, especially Parkinson's disease ( PD ) is challenging. Microstructural abnormalities of corpus callosum ( CC ) have been reported both in PSP and PD . The objective of this study was to compare the volumes of various segments of CC between patients with PSP ‐P, PSP ‐ RS , and early PD . Methodology This study included 32 patients with PSP ( RS : 18, P: 14), 20 patients with early PD , and 25 controls. All subjects underwent 3‐Tesla MRI . An automated surface‐based analysis package (FreeSurfer) was used to divide CC into five segments: anterior ( CC 1), midanterior ( CC 2), central ( CC 3), midposterior ( CC 4), and posterior ( CC 5). Volumes of these segments were compared among the four groups. Results The PSP ‐ RS group had significantly lower CC volume in all segments except in CC 1 and CC 5, whereas the volumes of the five segments of CC were comparable among PSP ‐P, PD and controls. The PSP ‐ RS group had lower CC 3 volume compared to the PSP ‐P group, and the PSP ‐ RS group had lower volume of both CC 2 and CC 3 compared to the PD group. Conclusions The lower volume of the central segment of CC ( CC 3) might help in differentiating PSP ‐ RS from PSP ‐P. There is no significant difference in the pattern of CC atrophy in PSP ‐P and early PD . Studies with higher sample sizes are warranted to confirm the results of our study.