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The Core Assessment Program for Surgical Interventional Therapies in Parkinson's Disease (CAPSIT‐PD): Tolerability of Preoperative Neuropsychological Testing for Deep Brain Stimulation in Parkinson's Disease
Author(s) -
Pal Gian D.,
Persinger Virginia,
Bernard Bryan,
Ouyang Bichun,
Goetz Christopher G.,
Verhagen Metman Leo
Publication year - 2015
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12213
Subject(s) - deep brain stimulation , parkinson's disease , medicine , tolerability , neuropsychology , disease , physical medicine and rehabilitation , psychiatry , adverse effect , cognition
Objective We examined tolerability of preoperative neuropsychological testing (the Core Assessment Program for Surgical Interventional Therapies in Parkinson's Disease [ CAPSIT ‐ PD] protocol) for DBS . We also examined factors that may influence tolerability, including fatigue, global cognitive function, depression, and patient‐based characteristics. Methods In this retrospective study, we reviewed preoperative neuropsychological testing results from 35 patients who were scheduled to undergo DBS . We examined the overall tolerability of the full battery and the tolerability of each test. We placed attention on a test's placement in the fixed order of the battery to measure whether there was a clustering of poorly tolerated tests toward the end of the battery as an indication of fatigue. Spearman's rank correlation was used to determine the relationship between tolerability and (1) global cognitive function, (2) depression, and (3) patient‐based characteristics. Results Fourteen subjects (40%) were able to tolerate the full battery and completed all 10 tests. The domains that were least tolerated pertained to executive function and procedural memory. There was a consistent time‐based tolerability pattern that was observed. There was a significant correlation between tolerability and global cognitive function ( ρ = 0.344; P = 0.043), but not depression ( P = 0.197). There was a significant correlation between tolerability and age ( ρ = −0.491; P = 0.003) and disease duration ( ρ = −0.442; P = 0.008), but not UPDRS ‐ III scores ( P = 0.284). Conclusion Our results have shown limited tolerability of the full neuropsychological battery as outlined by the CAPSIT ‐ PD protocol. We suggest the consideration of updating the neuropsychological assessment used in the CAPSIT ‐ PD protocol.