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Safe Administration of Botulinum Toxin Type A Injections During Pregnancy: A Report of Two Cases
Author(s) -
Krug Henriette,
Krause Patricia,
Kupsch Andreas,
Kühn Andrea A.
Publication year - 2015
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12135
Subject(s) - medicine , pregnancy , botulinum toxin , administration (probate law) , anesthesia , toxin , pharmacology , biology , political science , microbiology and biotechnology , law , genetics
Local injections of botulinum toxin type A (Bo NT /A) are safe and efficacious to treat focal and segmental dystonia. However, there are no adequate studies in humans regarding the safety of Bo NT /A during pregnancy. Despite the fact that 25 case reports have been published on patients who received Bo NT /A injections during a total of 31 pregnancies, in only 3 patients were the injections continued beyond the first trimester. We report on 2 females with cervical and segmental dystonia who received Bo NT /A injections during pregnancy beyond the first trimester and gave birth to 2 healthy children.