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Can Isolated Enlarged Virchow‐Robin Spaces Influence the Clinical Manifestations of Parkinson's Disease?
Author(s) -
Mestre Tiago A.,
Armstrong Melissa J.,
Walsh Richard,
Al Dakheel Amaal,
Moro Elena,
Stoessl A. Jon,
Lang Anthony E.
Publication year - 2014
Publication title -
movement disorders clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 18
ISSN - 2330-1619
DOI - 10.1002/mdc3.12009
Subject(s) - basal ganglia , parkinson's disease , medicine , disease , dopaminergic , pathology , dopamine , central nervous system
Dilated Virchow‐Robin ( VR ) spaces are usually not considered to be symptomatic. We present three cases presenting with atypical clinical features, which otherwise had clinical/imaging findings consistent with idiopathic Parkinson's disease. In all cases, an isolated large VR space in the basal ganglia contralateral to the side of symptom onset was observed. We propose that the atypical features could be associated with the mass effect of a significantly enlarged VR space, which would cause a dysfunction downstream from the presynaptic nigrostriatal dopaminergic system.