Open AccessNicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells
Author(s) -
Fang Tingting,
Yang Jingyun,
Liu Li,
Xiao Hengyi,
Wei Xiawei
Publication year - 2021
Publication title -
medcomm
Language(s) - English
Resource type - Journals
ISSN - 2688-2663
DOI - 10.1002/mco2.62
Subject(s) - senescence , nicotinamide mononucleotide , nad+ kinase , sirtuin , oxidative stress , bleomycin , respiratory system , biology , microbiology and biotechnology , medicine , cancer research , endocrinology , biochemistry , nicotinamide adenine dinucleotide , chemotherapy , enzyme
Alveolar epithelial cells (ACEs) gradually senescent as aging, which is one of the main causes of respiratory defense and function decline. Investigating the mechanisms of ACE senescence is important for understanding how the human respiratory system works. NAD + is reported to reduce during the aging process. Supplementing NAD + intermediates can activate sirtuin deacylases (SIRT1–SIRT7), which regulates the benefits of exercise and dietary restriction, reduce the level of intracellular oxidative stress, and improve mitochondrial function, thereby reversing cell senescence. We showed that nicotinamide mononucleotide (NMN) could effectively mitigate age‐associated physiological decline in the lung of 8–10 months old C57BL/6 mice and bleomycin‐induced pulmonary fibrosis in young mice of 6–8 weeks. Besides, the treatment of primary ACEs with NMN can markedly ameliorate cell senescence phenotype in vitro. These findings to improve the respiratory system function and reduce the incidence and mortality from respiratory diseases in the elderly are of great significance.