Open AccessSmall extracellular vesicles‐based cell‐free strategies for therapy
Author(s) -
Guo Yeye,
Wang Huaishan,
Huang Lili,
Ou Lingling,
Zhu Jinjin,
Liu Shujing,
Xu Xiaowei
Publication year - 2021
Publication title -
medcomm
Language(s) - English
Resource type - Journals
ISSN - 2688-2663
DOI - 10.1002/mco2.57
Subject(s) - extracellular vesicles , extracellular , mesenchymal stem cell , biology , biogenesis , cell therapy , intracellular , cell , microbiology and biotechnology , stem cell , biochemistry , gene
Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellular messenger regulating recipient cell function and play a role in disease initiation and progression. sEVs derived from certain cells, such as mesenchymal stem cells and immune cells, have the potential for clinical therapy as they possess the characteristics of their parental cells. With better understanding of sEVs biogenesis, their transportation properties, extended circulatory capability, and exceptional biocompatibility, sEVs emerge as a potential therapeutic tool in the clinic. Here, we summarize applications of sEVs‐based therapies in different diseases and current knowledge about the strategies in bioengineered sEVs, as well as the challenges for their use in clinical settings.