Open AccessModulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
Author(s) -
Xiang Yuancai,
Zhao Kun,
Tang YiQuan,
Dai Rongyang,
Miao Hongming
Publication year - 2021
Publication title -
medcomm
Language(s) - English
Resource type - Journals
ISSN - 2688-2663
DOI - 10.1002/mco2.44
Subject(s) - serine , alanine , chemistry , cytotoxicity , biochemistry , phosphorylation , amino acid , in vitro
A schematic illustration is given regarding serine restriction on tumor growth. Once the cellular abundance of serine decreased or alanine accumulated, the serine palmitoyltransferase (SPT) alternatively conjugates alanine and palmitoyl‐CoA to form 3‐keto‐intermediates, which is rapidly converted to 1‐deoxysphinganine and further metabolized to 1‐deoxydihydroceramide (1‐DeoxyDHCER) and 1‐deoxyceramide (1‐DeoxyDHCER), so that to exert cytotoxicity for tumor suppression.