Open AccessThe biological role of metabolic reprogramming in pancreatic cancer
Author(s) -
Suzuki Tatsunori,
Otsuka Motoyuki,
Seimiya Takahiro,
Iwata Takuma,
Kishikawa Takahiro,
Koike Kazuhiko
Publication year - 2020
Publication title -
medcomm
Language(s) - English
Resource type - Journals
ISSN - 2688-2663
DOI - 10.1002/mco2.37
Subject(s) - pancreatic cancer , reprogramming , biology , cancer research , disease , pancreatic ductal adenocarcinoma , metabolism , cancer , bioinformatics , medicine , cell , endocrinology , genetics
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease and highly resistant to all forms of therapy. PDAC cells reprogram their metabolism extensively to promote their survival and growth. Reflecting the vital role of altered metabolism, experimental and clinical trials targeting the rewired metabolism are currently underway. In this review, we summarize the vital role of metabolic reprogramming in the development of PDAC and the future of novel therapeutic applications.