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Genetic mapping and expression analysis of the murine DNA ligase I gene
Author(s) -
Gariboldi Manuela,
Montecucco Alessandra,
Columbano Amedeo,
LeddaColumbano Giovanna M.,
Savini Elena,
Manenti Giacomo,
Pierotti Marco A.,
Dragani Tommaso A.
Publication year - 1995
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.2940140202
Subject(s) - biology , dna ligase , chromosome , gene , microbiology and biotechnology , proliferating cell nuclear antigen , genetics , homologous chromosome , dna
We mapped the murine DNA ligase I gene ( Lig1 ) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver‐cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4–bis[2–(3,5—dichloropyridyloxy)]benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation. ©1995 Wiley‐Liss, Inc.