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Brief communications oncogene amplification per se: An independent prognostic factor in human breast cancer
Author(s) -
Champème MarieHélène,
Biéche Ivan,
Hacéne Kamel,
Lidereau Rosette
Publication year - 1994
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.2940110403
Subject(s) - biology , oncogene , breast cancer , cancer , cancer research , human breast , oncology , medicine , genetics , cell cycle
As the prognostic significance of the three most frequently amplified oncogenes in breast cancer ( c‐myc, int‐2IFGF3 , and c‐ erbB‐2lnew ) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate analysis in a group of 112 primary human breast cancer cases. Amplification of at least one gene (c‐ myc, int‐2lFGF3 , or c‐ erbB‐2Ineu) , progesterone receptor status, and pathological tumor size were the only independent variables predictive of metastasis‐free survival. Moreover, We constructed prognostic profilles by computing risks associated with the three parameters predictive of poor survival and disciminated high‐,moderate‐, and low‐risk categories. ©1994 Wiley‐Liss, Inc.