Premium
Cellular control of human papillomavirus oncogene transcription
Author(s) -
HoppeSeyler Felix,
Butz Karin
Publication year - 1994
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.2940100304
Subject(s) - biology , oncogene , carcinogenesis , transcription factor , viral oncogene , oncogene proteins , transcription (linguistics) , cell , cancer research , regulation of gene expression , microbiology and biotechnology , genetics , gene , cell cycle , linguistics , philosophy
Specific types of human papillomaviruses (HPVs) are closely associated with the development of cervical cancer. The transforming ability of these high‐risk HPV types depends on the expression of the viral E6 and E7 oncogenes. It is therefore of particular interest to elucidate the molecular mechanisms that result in the activation of E6/E7 expression during HPV‐associated tumorigenesis. Recently, much progress has been made in characterizing the proteins involved in the regulation of HPV oncogene transcription. This review describes the functional significance of cellular factors involved in the transcriptional control of the E6/E7 promoter for the two most common HPV types associated with cervical cancer, HPV16 and HPV18. In addition, we discuss regulatory pathways that may contribute to the epithelial cell specificity of E6/E7 transcription. The definition of the factors that regulate HPV oncogene transcription could provide new insights into the molecular mechanisms activating viral oncogene expression during cervical carcinogenesis and forms an experimental basis for investigating the specific biochemical pathways that contribute to HPV‐associated malignant cell transformation. © 1994 Wiley‐Liss, Inc.