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Characterization of cell lines derived from formaldehyde‐induced nasal tumors in rats
Author(s) -
Bermudez Edilberto,
Chen Zhuchu,
Gross Elizabeth A.,
Walker Cheryl L.,
Recio Leslie,
Pluta Linda,
Morgan Kevin T.
Publication year - 1994
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.2940090403
Subject(s) - biology , carcinogenesis , cell culture , epidermal growth factor receptor , keratin , respiratory tract , cancer research , gene , microbiology and biotechnology , receptor , respiratory system , genetics , anatomy
Cell lines derived from formaldehyde‐induced nasal tumors in Fischer 344 rats were established. All of the lines were found to be epithelial and aneuploid and to express keratin, transforming growth factor‐α, and epidermal growth factor receptor transcripts. Two of four lines were tumorigenic upon injection into nude mice, and these lines also contained point mutations in the p53 suppressor gene. The data indicate that these lines possess characteristics that make them a valuable tool for the study of chemically induced respiratory tract carcinogenesis. © 1994 Wiley‐Liss, Inc.