Premium
Lack of mutations of the p53 tumor suppressor gene in hepatocellular carcinomas induced in rats by a peroxisome proliferator
Author(s) -
Smith Martin L.,
Yeleswarapu Lakshmi,
Lombardi Benito,
Shinozuka Hisashi
Publication year - 1993
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.2940070206
Subject(s) - biology , peroxisome proliferator , tumor suppressor gene , gene , suppressor , carcinogen , hepatocellular carcinoma , cancer research , peroxisome , peroxisome proliferator activated receptor , immunohistochemistry , mutation , medicine , endocrinology , microbiology and biotechnology , carcinogenesis , genetics , immunology
Immunohistochemical, immunoblotting, and DNA‐sequencing analyses were performed on hepatocellular carcinomas induced in rats chronically fed BR931, a peroxisome proliferator, to determine whether the tumors carried mutations or other alterations of the p53 gene. None were detected. Inactivation of this tumor suppressor gene does not appear, therefore, to be involved in the carcinogenicity of BR931, a nongenotoxic chemical hepatocarcinogen.