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Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase
Author(s) -
St. Clair Daret K.,
Steven Wan X.,
Oberley Terry D.,
Muse Kenneth E.,
St. Clair William H.
Publication year - 1992
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.2940060404
Subject(s) - biology , superoxide dismutase , neoplastic transformation , transformation (genetics) , microbiology and biotechnology , cancer research , genetics , biochemistry , cancer , oxidative stress , carcinogenesis , gene
Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation‐, but not chemically‐induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation. © 1992 Wiley‐Liss, Inc.