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Cellular oncogene expression in cell lines derived from tumors produced by transformed rat tracheal epithelial cells
Author(s) -
Walker Cheryl,
Nettesheim Paul
Publication year - 1989
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.2940020302
Subject(s) - biology , oncogene , cell culture , cell , 3t3 cells , microbiology and biotechnology , tumor cells , cancer research , cell cycle , transfection , genetics
Five tumor‐derived cell lines established from transformed rat tracheal epithelial (RTE) cells were examined for activated oncogenes using the NIH 3T3 assay, and the expression of 11 cellular oncogenes in the transformed cells was quantitated and compared with expression in normal RTE cells. DNA from the tumor‐derived cell lines lacked transforming activity, but expression of several oncogenes ( fos, abl , Ki‐ ras , Ha‐ ras , and p53) was higher in the transformed cells than in normal RTE cells.