Premium
Alternative splicing: An important regulatory mechanism in colorectal carcinoma
Author(s) -
Wang Jianyi,
Wang Chuhan,
Li Le,
Yang Lirui,
Wang Shuoshuo,
Ning Xuelian,
Gao Shuangshu,
Ren Lili,
Chaulagain Anita,
Tang Jing,
Wang Tianzhen
Publication year - 2021
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.23291
Subject(s) - biology , alternative splicing , rna splicing , mechanism (biology) , carcinogenesis , chromatin , computational biology , messenger rna , precursor mrna , signal transduction , gene isoform , colorectal cancer , cancer research , bioinformatics , microbiology and biotechnology , genetics , gene , cancer , rna , philosophy , epistemology
Alternative splicing (AS) is a process that produces various mRNA splicing isoforms via different splicing patterns of mRNA precursors (pre‐mRNAs). AS is the primary mechanism for increasing the types and quantities of proteins to improve biodiversity and influence multiple biological processes, including chromatin modification, signal transduction, and protein expression. It has been reported that AS is involved in the tumorigenesis and development of colorectal carcinoma (CRC). In this review, we delineate the concept, types, regulatory processes, and technical advances of AS and focus on the role of AS in CRC initiation, progression, treatment, and prognosis. This summary of the current knowledge about AS will contribute to our understanding of CRC initiation and development. This study will help in the discovery of novel biomarkers and therapeutic targets for CRC prognosis and treatment.