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Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis
Author(s) -
Lu Kai,
Bhat Madhavi,
Peters Sara,
Mitra Rita,
Oberyszyn Tatiana,
Basu Sujit
Publication year - 2021
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.23281
Subject(s) - carcinogenesis , angiogenesis , biology , cancer research , receptor , beta (programming language) , vascular endothelial growth factor , cell , cell growth , basal cell , vegf receptors , medicine , cancer , biochemistry , genetics , computer science , programming language
Although beta 2 adrenergic receptors (β 2 ADR) are present in the keratinocytes, their role in cutaneous squamous cell tumorigenesis needs to be ascertained. For the first time, we report here that selective β 2 ADR antagonists by inhibiting β 2 ADR actions significantly retarded the progression of ultraviolet B (UVB) induced premalignant cutaneous squamous cell lesions. These antagonists acted by inhibiting vascular endothelial growth factor‐A (VEGF) mediated angiogenesis to prevent UVB radiation‐induced squamous cell carcinoma of the skin.