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IL‐1RN gene polymorphisms reduces thyroid cancer risk in Chinese Han population
Author(s) -
Li Huajing,
Wu Yue,
Zhao Ruimin,
Chen Xin,
Ren Wanli,
Li Honghui,
Han Peng,
Shao Yuan,
Wang Jiansheng
Publication year - 2020
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.23244
Subject(s) - single nucleotide polymorphism , odds ratio , biology , logistic regression , genotype , confidence interval , medicine , allele , thyroid cancer , oncology , polymorphism (computer science) , gene , endocrinology , thyroid , genetics
The purpose of this study was to investigate the effect of IL‐1RN polymorphisms on thyroid cancer (TC) risk in Han population. Genotypes of four single nucleotide polymorphisms (SNPs) (rs17042888, rs928940, rs3181052, and rs452204) were analyzed by Agena MassARRAY. Meanwhile, we used the logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs), and significant differences were evaluated by t test and χ 2 test. Findings found that allele “G” of rs452204 and rs3181052 in interleukin‐1 receptor antagonist ( IL‐1RN ) reduced the risk of TC. (OR = 0.72, 95% CI = 0.55‐0.94, p = .017; OR = 0.73, 95% CI = 0.56‐0.94, p = .017, respectively). Hierarchical analysis indicated that three SNPs (rs17042888, rs3181052, and rs452204) significantly reduced the risk of TC among females or individuals older than 48 years ( p < .05). Our findings indicate that IL‐1RN polymorphisms may contribute to a protective role against TC risk.