Premium
YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma
Author(s) -
Du Jing,
Ren Wenyan,
Yao Fengping,
Wang Hong,
Zhang Kexin,
Luo Meiying,
Shang Yuxue,
O'Connell Douglas,
Bei Zhuchun,
Wang Hongquan,
Xiong Ran,
Yang Yongfei
Publication year - 2019
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.23105
Subject(s) - tfeb , autophagy , biology , microbiology and biotechnology , bag3 , transcription factor , biogenesis , basic helix loop helix leucine zipper transcription factors , lysosome , atg16l1 , cancer research , gene , genetics , biochemistry , dna binding protein , apoptosis , enzyme
Autophagy is a self‐proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) is the master activator that regulates the transcription of genes involved in autophagy and lysosomal biogenesis. However, the cotranscriptional factors of TFEB are rarely identified. Here, we found that Yin Yang 1 (YY1) regulated autophagy and lysosome biogenesis in melanoma cells. YY1 cooperates with TFEB to regulate autophagy through controlling the transcription of autophagy and lysosome biogenesis related genes. Moreover, suppression of YY1 enhanced the antitumor efficiency of vemurafenib both in vitro and in vivo. Collectively, these studies identify YY1 as a novel cotranscription factor of TFEB in regulating autophagy and lysosomal functions and suggest YY1 could be a therapeutic target in cancer treatment.