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CNBP controls tumor cell biology by regulating tumor‐promoting gene expression
Author(s) -
Lee Eunhye,
Lee Taeyun A.,
Yoo Hye Jin,
Lee Sungwook,
Park Boyoun
Publication year - 2019
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.23030
Subject(s) - biology , transcription factor , gene expression , regulation of gene expression , microbiology and biotechnology , gene , cell , genetics
Abstract Cellular nucleic acid‐binding protein (CNBP) is associated with cell proliferation, and its expression is elevated in human tumors, but the molecular mechanisms of CNBP in tumor cell biology have not been fully elucidated. In this study, we report that CNBP is a transcription factor essential for regulating matrix metalloproteinases mmp‐2 , mmp‐14 , and transcription factor e2f2 gene expression by binding to their promoter regions via a sequence‐specific manner. Importantly, epidermal growth factor stimulation is required to induce CNBP phosphorylation and nuclear transport, thereby promoting the expression of mmp‐2 , mmp‐14 , and e2f2 genes. As a consequence, loss of cnbp attenuates the ability of tumor cell growth, invasion, and migration. Conversely, overexpression of cnbp is associated with tumor cell biology. Collectively, our findings reveal CNBP as a key transcriptional regulator of tumor‐promoting target genes to control tumor cell biology.