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Exosome‐transmitted p120‐catenin suppresses hepatocellular carcinoma progression via STAT3 pathways
Author(s) -
Cheng Zhangjun,
Lei Zhengqing,
Yang Pinghua,
Si Anfeng,
Xiang Daimin,
Tang Xuewu,
Guo Guangmeng,
Zhou Jiahua,
Hüser Norbert
Publication year - 2019
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.23022
Subject(s) - microvesicles , exosome , biology , metastasis , cancer research , hepatocellular carcinoma , liver cancer , catenin , cancer stem cell , tumor progression , cancer , stat3 , cancer cell , stem cell , microrna , signal transduction , microbiology and biotechnology , wnt signaling pathway , biochemistry , genetics , gene
Hepatocellular carcinoma (HCC) is a fatal disease with increasing morbidity and poor prognosis due to surgical recurrence and metastasis. Moreover, the molecular mechanism of HCC progression remains unclear. Although the role of p120‐catenin (p120ctn) in liver cancer is well studied, the effects of secreted p120ctn transported by exosomes are less understood. Here, we show that p120ctn in exosomes secreted from liver cancer cells suppresses HCC cell proliferation and metastasis and expansion of liver cancer stem cells (CSCs). Mechanically, exosome p120ctn inhibits HCC cell progression via the STAT3 pathway, and the STAT3 inhibitor S3I‐201 abolishes the observed effects on growth, metastasis, and self‐renewal ability between exosome p120ctn‐treated HCC cells and control cells. Taken together, we propose that p120ctn‐containing exosomes derived from cancer cells inhibit the progression of liver cancer and may offer a new therapeutic strategy.